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Yes, the American Heart Association considers 12 pounds per week (48 pounds monthly) to be safe and sustainable weight loss

But even then, it should be understood as an experimental deviation from the standard, not the default

Together, they engage two separate hormonal systems that both regulate body weight creating an additive, and potentially synergistic, effect on appetite suppression and calorie reduction

In a Phase 2 clinical trial involving adults with obesity, participants receiving the highest dose achieved an average weight reduction approaching 24% at 48 weeks , among the largest weight losses reported with a medication

(Learn more about heart monitoring on the Long-Term Monitoring page)